ABT-199 is a BH3 mimetic that inhibits Bcl-2 but does not affect Bcl-xl. ABT-199 exhibits anticancer chemotherapeutic activity, inducing Bim-mediated apoptosis in chronic lymphocytic leukemia (CLL) cells. ABT-199 also induces cell death and inhibits tumor growth in acute myelogenous leukemia (AML) models in vitro, ex vivo, and in vivo. ABT-199 is currently under examination as a potential treatment for CLL.

https://lktlabs.com/product/abt-199/

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