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E6781,(±)-EQUOL,94105-90-5
商品品牌:LKT Laboratories,Inc
商品编号:20011716240449
产品积分:1882
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市场价格:¥1881.6元
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产品编号:E6781
产品名称:(±)-EQUOL(Cas No.94105-90-5)
产品说明:

Equol is a soy isoflavone and phytoestrogen used in veterinary medicine that acts as an agonist at estrogen receptors. Equol is the major metabolite of daidzein and exhibits anti-aging, antioxidative, estrogenic, anti-inflammatory, and chemopreventive activities. In vitro, equol increases expression of extracellular matrix proteins collagen and elastin as well as nerve growth factor (NGF) and decreases expression of aging genes and pro-inflammatory cytokines such as matrix metalloproteinases 1, 3, and 9 (MMP1/3/9), COX-1, IL-6, and IL-1α. In fibroblasts, equol inhibited ROS generation and oxidative stress. In animal models, equol increases activity of catalase, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase. Additionally, equol inhibits TNF-α production, NF-κB activation, and IκB kinase degradation in macrophages. This compound increases activation of p53, caspase 3, and poly(ADP)-ribose polymerase (PARP), increases expression of p21 and Bax, and decreases expression of Bcl-2, resulting in apoptosis and inhibition of tumor formation in animal models.
规格:10mg

报价:1881.60元

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