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This product is the non-natural L-threo stereoisomer of ceramide. Natural D-erythro ceramide is a critical compound in cells both as a free ceramide and incorporated into more complex sphingolipids. L-threo-ceramides demonstrate a different metabolic functionality from natural ceramides. They have been shown to be metabolized to sphingomyelin but not to glucosylceramide.1 Another non-natural stereoisomer, L-erythro ceramide, is not metabolized to any sphingolipid. In contrast to natural ceramides L-threo ceramides are unable to antagonize the disruptive effects of fumonisin B1 on axon growth2 but it is able to activate intracellular pathways and induces apoptosis.3 The deacylated form of ceramide, sphingosine, also has many critical cellular functions. L-threo-sphingosine, along with other sphingosine isomers, has been found to be an activator of 3-Phosphoinositide-dependent kinase-14 and inhibits protein kinase C a little more potently than D-erythro-sphingosine.5

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名称: 深圳市明博林生物科技有限公司
税务登记号 9144030055718808X9
地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A
电话: 0755-25106053
开户银行: 中国工商银行深圳红宝支行
账号: 4000024839200103206

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