|
|
|
|
https://www.matreya.com/search.aspx?keyword=1806
L-threo-Sphingosine is an inactive or less active isomer of the naturally occurring D-erythro-sphingosine. Natural sphingosine induces dephosphorylation of retinoblastoma gene products and inhibits cell growth while L-threo-sphingosine is less active. However, the L-threo-sphingosine is taken up by cells to the same extent as the natural sphingosine indicating that cellular uptake was not the factor influencing activity.1 L-threo-sphingosine, along with other sphingosine isomers, has been found to be an activator of 3-Phosphoinositide-dependent kinase-1.2 Natural D-erythro-sphingosine is a positive regulator of cell growth in fibroblasts whereas L-threo-sphingosine has no regulatory effect.3 However, non-natural stereoisomers of sphingosine are not always inactive; L-threo-sphingosine has been shown to inhibit protein kinase C a little more potently than D-erythro-sphingosine.4 Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others. It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18-carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. Lysosphingolipids inhibit protein kinase C activity resulting in the pathogenesis of sphingolipidoses such as Krabbe's disease and Gaucher's disease. Sphingosine can be phosphorylated via two kinases to form sphingosine-1-phosphate, which has important signaling functions. While sphingosines and ceramides can induce apoptosis, sphingosine-1-phosphate can promote cell survival or proliferation. Sphingosine has been shown to cause an increase in the cytoplasmic calcium level of cells.
|
更多信息 >>
银行转账 |
|
我司银行账户:
名称: 深圳市明博林生物科技有限公司 税务登记号 9144030055718808X9 地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A 电话: 0755-25106053 开户银行: 中国工商银行深圳红宝支行 账号: 4000024839200103206
|
在线支付 |
|
请在我们订单-订单详情-点击底部支付按钮直接进行在线支付
在线支付需要您的银行账户开通在线支付功能 |
更多信息 >>
深圳地区 |
|
深圳地区统一采用快递送货,一个工作日送达,快递费用5元; |
其它地区 |
|
1. 快递送货 每单10元 2-3日到达 推荐! 2. 邮局邮寄 每单5元 5-7日到达 |
|
|