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This product inhibits the growth of cells, including cancer cells. D-threo-PDMP has been shown to inhibit cell growth by inhibiting the enzyme glucosylceramide synthase1 but erythro-PDMP inhibits growth according to a different mechanism. PDMP has four possible isomers (D-threo, L-threo, D-erythro, and L-erythro) due to its two chiral centers. This product (D,L-erythro-PDMP) is a mixture of D-erythro (1R,2R) and L-erythro (1S,2S). The D-threo isomer has been shown to be the active glucosyl ceramide synthetase inhibitor.2 Although erythro-PDMP does not inhibit glucosylceramide synthase it does cause cell growth inhibition similar to threo-PDMP.3 This has been suggested as a treatment for cancer.4 In addition to its stereochemistry, the acyl chain of PDMP has a very marked effect on the intensity of the inhibitory action of the molecule.

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名称: 深圳市明博林生物科技有限公司
税务登记号 9144030055718808X9
地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A
电话: 0755-25106053
开户银行: 中国工商银行深圳红宝支行
账号: 4000024839200103206

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