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N-Dodecanoyl-NBD-L-threo-dihydrosphingosine is a synthetic dihydroceramide analog containing the 7-(4-nitrobenzo-2- oxa-1,3-diazole) (NBD) fluorescent group. NBD has been shown to have only a small influence on lipid adsorption into cells and cellular membranes in many applications. This fluorescent analog of L-threo-dihydroceramide is comparable to C12:0- L-threo-dihydroceramide in some biological functions. Safingol is a fully saturated, non-natural analog of sphingosine that has anticancer properties and is being investigated for its potential as an antitumor therapy. It has been shown to inhibit both protein kinase C (PKC) and sphingosine kinase. Safingol competitively interacts at the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. Safingol has been shown to potentiate the effect of doxorubicin (DOX) in tumorbearing animals.1 It has been reported that safingol is able to increase the activity of DOX and other chemotherapeutic agents, including mitomycin C, by generating the pro-apoptotic second messenger ceramide, even in tumor cell lines that were resistant to chemotherapy due to mutations.2 However, a study has recently claimed that safingol induces cell death of an exclusively autophagic character and lacking any of the hallmarks of apoptosis.3 Safingol inhibited the reactive oxygen intermediates (ROI) released from isolated neutrophils and phorbol ester-induced edema and neutrophil influx. Safingol also demonstrates anti-inflammatory activity. Safingol, like the natural D-erythro-sphinganine, is used as a biosynthetic precursor for all complex sphingolipids althogh the metabolism of the natural and the non-natural compounds are different.4

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名称: 深圳市明博林生物科技有限公司
税务登记号 9144030055718808X9
地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A
电话: 0755-25106053
开户银行: 中国工商银行深圳红宝支行
账号: 4000024839200103206

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