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This product is a high purity, well-defined phosphorylglycerol acylated with the common stearic acid, making it useful as a standard and for biological studies. Phosphorylglycerols are found in pulmonary surfactants, the lipoprotein complex that is formed by typeII alveolar cells in the lung. They are important in spreading secreted surfactants over the typeI alveolar cells. A decreased level of phosphorylglycerol in cystic fibrosis respiratory mucus is partly responsible for its marked adhesiveness and stickiness, which impairs mucus transport, and distearoyl phosphorylglycerol (DSPG) has been shown to be the most efficient form of phosphorylglycerol in the enhancement of respiratory mucus clearance.1 The enzyme cardiolipin synthase attaches two phosphorylglycerols together to form cardiolipid which is a major component of the mitochondrial inner membrane.2 Phosphorylglycerol is the main component of some bacterial membranes where it contains diacyl, alkylacyl, or alkenylacyl groups. Phosphorylglycerols generally have saturated and monoenoic fatty acids on position sn-2 and polyunsaturated fatty acids in position sn-1. This is the opposite of the other animal phospholipids and is due to its being synthesized by a different mechanism. Phosphorylglycerol has been found to be essential for the development of thylakoid membranes in some plants.3 Besides being critical in membranes it is essential for the oligomerization of photosystems I and II in cyanobacteria, for the sensitivity to chilling in plants, and for cellular fission and division in bacteria. DSPG has a high transition temperature and has therefore found much use in liposomal drug delivery systems.4 Amphotericin B, an antifungal drug, exhibits significant toxicity towards host cells. Studies using phosphorylglycerol have shown that interactions between amphotericin B and this phospholipid reduces its toxicity towards host cells.5

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名称: 深圳市明博林生物科技有限公司
税务登记号 9144030055718808X9
地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A
电话: 0755-25106053
开户银行: 中国工商银行深圳红宝支行
账号: 4000024839200103206

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